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Many translated example sentences containing "pets" – German-English dictionary and search engine for German translations. Pets (Originaltitel: The Secret Life of Pets) ist ein US-amerikanischer Computeranimationsfilm von Illumination Entertainment aus dem Jahr Der Film der. Pets or Haustiere, how they are called in German, are human's best friends. And there is a myriad of studies that confirm that Hunde ('dogs'), Katzen ('cats'). Englisch-Deutsch-Übersetzungen für pet im Online-Wörterbuch mitthjartaloppet.se (Deutschwörterbuch). Pets in German. 1. You need to use your mouse to see this presentation © Heidi Behrens; 2. Haustiere (pets); 3. The little word ' the ' In.
Pets or Haustiere, how they are called in German, are human's best friends. And there is a myriad of studies that confirm that Hunde ('dogs'), Katzen ('cats'). Director: JГ©rГґme Cornuau. Starring: Fanny Ardant, Eric Elmosnino, Marina Hands. Subtitles: Deutsch. Audio languages: Français. This video is currently. Pets in German. 1. You need to use your mouse to see this presentation © Heidi Behrens; 2. Haustiere (pets); 3. The little word ' the ' In.
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The substances are intended as nutritional additives under the functional group vitamins, pro-vitamins and chemically well-defined substances having similar effects, for all animal species and categories.
Characterisation 2. The structural formula of L-carnitine is shown in Figure 1. OJ L 6. OJ L OJ L 15, L-Carnitine is a white to beige odourless hygroscopic powder.
The analysis of five batches of the product showed an average content of The main impurity, 4-hydroxycrotonic acid, was below 0.
Production batches are routinely screened for chemical and microbial contamination and impurities.
Six batches of L-carnitine were analysed for particle size distribution determined by laser diffraction.
The additive three batches showed a low dusting potential of 0. The structural formula of L-carnitine L-tartrate is shown in Figure 2.
Figure 2: Structural formula of L-carnitine L-tartrate. The Analysis of five batches of the product showed an average content of L-carnitine, L-tartaric acid and water of Data for residual solvents indicated that VICH thresholds for class 2 and 3 are not exceeded.
Three batches of L-carnitine L-tartrate were analysed for particle size distribution determined by laser diffraction. The substance showed a dusting potential of 0.
Manufacturing process 2. L-Carnitine L-Carnitine is produced by a two-step chemical synthesis process. In the first step, a solution of ethyl 4-chloroacetoacetate in ethanol is hydrogenated using a chiral catalyst.
In the second step, ethyl R -4chlorohydroxybutyrate is aminated with trimethylamine and hydrolysed with aqueous sodium hydroxide, giving L-carnitine.
The obtained aqueous L-carnitine solution is electrodialysed and recrystallised in an organic solvent and then dried. The applicant provided a flow chart of the synthetic process.
L-Carnitine L-tartrate L-Tartaric acid in an organic solvent is added to an aqueous solution of L-carnitine.
The solution is cooled and centrifuged. The resultant L-carnitine L-tartrate crystals are then dried.
Stability and homogeneity 2. L-Carnitine 2. Feed processing did not affect the concentration of L-carnitine in feed.
After storage for three months at 25 C no reduction in the content of L-carnitine was observed. L-Carnitine L-tartrate 2.
Stability of the additive when added to premixtures, feed and drinking water The applicant provided no information on the stability of L-carnitine L-tartrate in premixtures and complete feed, but stated that the stability of L-carnitine L-tartrate is similar to that of L-carnitine.
However, even when hydrolysis occurs the Lcarnitine component is likely to be stable. The coefficient of variation was 5. Therefore, homogeneity in water for drinking need not be demonstrated.
No such incompatibilities or interactions were expected. Conditions of use L-carnitine and L-carnitine L-tartrate are intended for use via feed premixtures, complete or complementary feed and water for drinking in all animal species and categories without a maximum content or withdrawal period.
Safety for the target species L-Carnitine is well tolerated by humans and all animal species, possibly because of its decreasing bioavailability with increasing dietary L-carnitine concentrations.
In studies with Japanese quail Coturnix coturnix subsp. Conclusions on the safety for target species Based on the literature it can be concluded that L-carnitine and L-carnitine L-tartrate are safe for the target species.
Safety for the consumer 3. Absorption, distribution, metabolism, residues and excretion After ingestion L-carnitine is absorbed in the small intestine via a sodium-dependent transport system low carnitine concentration or at pharmacological doses of carnitine via passive diffusion as free carnitine and short-chain carnitine esters Shaw et al.
The major portion of all carnitine in the body is found in the skeletal muscle see, for example, Mitchell Studies with labelled L-carnitine suggest that carnitine is usually largely not metabolised e.
A dose of 3 g L-carnitine L-tartrate given daily to volunteers for three weeks was tolerated.
It was tested at concentrations of 1. There were two independent experiments. There was no evidence of gene mutation EFSA, Assessment of consumer safety No acceptable daily intake or tolerable upper intake level has been established for L-carnitine or Lcarnitine L-tartrate.
L-Carnitine is present in the human diet in a variety of food sources. Conclusions on the safety for the consumer Based on residue data described under section 3.
Safety for the user 3. In the absence of data on the inhalation toxicity of L-carnitine and Lcarnitine L-tartrate, inhalation of dust is considered to be potentially hazardous.
Effects on the eyes and skin 3. The results indicate that L-carnitine is not a skin sensitiser. The results therefore indicate that Lcarnitine L-tartrate is non-irritant.
For an acute eye irritation study OECD guideline 0. It was concluded that L-carnitine L-tartrate is non-irritant to eyes. OJ C , The results suggested that L-carnitine L-tartrate is not a skin sensitiser.
Conclusions on the safety for the user L-Carnitine and L-carnitine L-tartrate are not irritating to skin and eyes and are not skin sensitisers.
LCarnitine and L-carnitine L-tartrate in the formulations described show limited dust formation. As no information is available on inhalation toxicity, adverse effects on the respiratory tract cannot be fully excluded.
Safety for the environment Carnitine is a naturally occurring substance, present in all animals and bacteria and, to a lesser extent, in some plants.
Its use in animal nutrition is not expected to substantially increase the concentration in the environment. Therefore, any risk to the environment resulting from the use of carnitine in animal nutrition is not foreseen.
Intensive research has been done on the action of L-carnitine in the fatty acid and energy metabolism of humans and animals; a number of studies also deal with the effect of additional dietary L-carnitine on endogenous carnitine concentrations and fat and energy utilisation, as well as on the performance of various livestock animals e.
Dubelaar et al. However, the carnitine doses stated to be effective for improving the performance varied not only among the species investigated but also for one species between the research groups.
Moreover, the occurrence of a carnitine effect is often inconsistent, possibly depending on the experimental diets, particularly the presence of the precursors, age and growth rate of the animal and the general experimental conditions e.
Burtle, ; Litz, ; Schuhmacher et al. In studies with piglets and freshly hatched quail L-carnitine appeared to improve weight gain and feed efficiency only if the metabolic precursors lysine or methionine were deficient in the diets Schuhmacher et al.
However, it seems very unlikely that an amino acidsparing effect on a molar basis was responsible for these findings. Post-market monitoring The FEEDAP Panel considers that there is no need for a specific post-market monitoring plan, other than the requirements established in the Feed Hygiene Regulation35 and good manufacturing practice.
OJ L 35, 8. Nevertheless, based on residue data obtained from multi-fold doses of the levels typically use, the FEEDAP Panel concluded that typical supplementation of feed with L-carnitine or L-carnitine L-tartrate would not substantially increase human exposure to carnitine from food of animal origin.
L-Carnitine and L-carnitine L-tartrate are not irritant to skin and eyes, nor are they skin sensitisers.
LCarnitine and L-carnitine L-tartrate show limited dust formation. As inhalation toxicity studies are not available, adverse effects in the respiratory tract cannot be fully excluded.
L-Carnitine and L-carnitine L-tartrate as a feed additive for all animal species. October Submitted by Lonza Benelux BV.
L-Carnitine 3. L-Carnitine 4. Comments from Member States received through the ScienceNet. Supplementary information.
February Vitamins in Animal Nutrition. ISBN Bremer J, L-Carnitine supplementation of sows during pregnancy improves the suckling behaviour of their offspring.
The influence of two different dosages of L-carnitine on some blood parameters during exercise in trained pigeons.
Turnover of carnitine by rat tissues. Burtle GJ, L-Carnitine enhanced fish growth. Presentation at Carnitine seminar, Lonza, Basel.
Effects of dietary L-carnitine supplements on growth and muscle lipid of fingerling channel catfish. Report to Lonza, Basel. Carnitine intake and excretion in neuromuscular diseases.
Radioisotopic determination of L-carnitine content in foods commonly eaten in Western countries. The effect of L-carnitine on force development of the latissimus dorsi muscle in dogs.
Acute effect of L-carnitine on skeletal muscle force tests in dogs. EFSA Journal 9 6 : , 24pp. European Pharmacopeia PhEur , Levocarnitine, Monograph MG , 7th edition.
Falaschini A and Trombetta MF, Supplementation of L-carnitine in pigs: absorption of carnitine and effect on plasma and tissue carnitine concentrations.
The effect of oral L-carnitine supplementation on the muscle and plasma concentrations in the Thoroughbred horse.
Comparative Biochemistry and Physiology. Part A. Effect of training and L-carnitine on long-term exercise in pigeon.
Kurzfassung, A study on the carnitine metabolism of early weaned piglets. Dissertation vet. Bestimmung von L-Carnitin und seiner Ester in Lebensmitteln.
Hamburg, University, Fachbereich Chemie, Dissertation. In vivo studies of intestinal carnitine absorption in rats.
Carnitine transport in human intestinal biopsy specimens. Demonstration of an active transport system. Pharmacokinetics of intravenous and oral bolus doses of L-carnitine in healthy subjects.
Plasma carnitine concentration and uptake into muscle following oral and intravenous administration. Equine Veterinary Journal, 18, Dietary L-carnitine improves nitrogen utilization in growing pigs fed low energy, fat-containing diets.
A study on the carnitine status of baby quail Coturnix coturnix japonica. Atlantic salmon Salmo salar fed L-carnitine exhibit altered intermediary metabolism and reduced tissue lipid, but no change in growth rate.
Kliemant A, Studies on the carnitine metabolism of Japanese quail Coturnix coturnix japonica. The determination of L-carnitine in several food samples.
Food Chemistry, , Uptake of Lcarnitine by rat jejunal brush border microvillous membrane vesicles.
Evidence of passive diffusion. Lindstedt G and Lindstedt S, On the biosynthesis and degradation of carnitine. Litz H, Examination of the overall effect of a L-carnitine addition to piglet starter diets and to diets for rainbow trout Oncorhynchus mykiss.
Dissertation med. L-Carnitine and carnitine ester transport in the rat small intestine. McDowell LR, Vitamins in Animal and Human Nutrition, 2nd edition.
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